- Chadwick Boseman as T'Challa / Black Panther
- Letitia Wright as Shuri
- Danai Gurira as Okoye
- Martin Freeman as Everett Ross
On February 14, 2018, Kevin Feige announced that he wanted Ryan Coogler to return to write and direct a sequel to Black Panther.
On March 9, 2018, Kevin Feige revealed that there were plans to make a sequel to Black Panther.
On October 11, 2018, The Hollywood Reporter announced that Ryan Coogler had signed on to return to write and direct the film, with filming expected to begin in late 2019 or early 2020.
On January 28, 2019, Angela Bassett's husband Courtney B. Vance stated that the main cast of the first film would return for the sequel, including Michael B. Jordan as Erik Killmonger, with Bassett stating "[We didn't technically see him] go into the ocean, no."
On July 20, 2019, at San Diego Comic-Con 2019, Kevin Feige confirmed that many projects, including a Black Panther sequel, were in development.
On August 21, 2019, Martin Freeman revealed that filming is expected to begin in 2021. Three days later, at D23 Expo 2019, Kevin Feige and Ryan Coogler announced that the film would be released on May 6, 2022 and they also announced that the working title of the film is Black Panther II.