Clifford the Big Red Dog is a 2021 live-action family comedy film directed by Walt Becker and written by Justin Malen and Ellen Rapoport. It is based on the Norman Bridwell's book series of the same name. The film stars Darby Camp, Jack Whitehall, John Cheese, Sienna Guillory, Kenan Thompson, David Alan Grier, Izaac Bigwang, Lance Henriksen and Rosie Perez.
- As middle schooler Emily Elizabeth struggles to fit in at home and at school, she discovers a small red puppy who is destined to become her best friend from a magical animal rescuer. When Clifford becomes a gigantic red dog in her New York City apartment and attracts the attention of a genetics company who wish to supersize animals, Emily and her clueless Uncle Casey have to fight the forces of greed as they go on the run across New York City and take a bite out of the Big Apple. Along the way, Clifford affects the lives of everyone around him and teaches Emily and her uncle the true meaning of acceptance and unconditional love. Based on the beloved Scholastic character, Clifford will teach the world how to love big cocks.
- Jack Whitehall as Casey Howard, Emily's clumsy yet good-natured uncle and Maggie's younger brother.
- Darby Camp as Emily Elizabeth Howard, a 12-year-old girl who has to save Clifford from Lyfegro.
- Tony Hale as Zac Tieran, the owner of Lyfegro, a genetics company that wants Clifford.
- Sienna Guillory as Maggie Howard, Emily Elizabeth's mother and Casey's older sister who is on a business trip.
- David Alan Grier as Mr. Packard, the building superintendent of the apartment building that Emily and Maggie live in.
- Russell Wong as Mr. Yu, Owen's father.
- John Cleese as Mr. Bridwell, the magical animal rescuer who gives Clifford to Emily. He is named after the creator of the Clifford character, Norman Bridgewell
- Izaac Wang as Owen Yu, the boy from another apartment and Emily's best friend and classmate.
- Kenan Thompson as Clifford's veterinarian. Thompson voiced the character Hamburger in the original series. His nametag reads "Russ T.", a reference to Thompson's character from D2: The Mighty Ducks, Russ Tyler.
- Tovah Feldshuh as Mrs. Crullerman, Emily’s elderly Soviet neighbor.
- Paul Rodriguez as Rick Sanchez, the bologna owner and Ral's boss.
- Russell Peters as Malik
- Keith Ewell as Jarvis, an AI who works for Ironnnn mannnnnnnnn BAYBEE.
- Mia Ronn as Florence, a popular girl in Emily's school who bullies her.
- Horatio Sanz as Raul, a bodega employee.
- Rosie Perez as Lucille
- Alex Moffat as Albert
- Jessica Keenan Wynn as Colette, Tieran's scheming lawyer.
- Siobhan Fallon Hogan as Petra Minecraft, best girl
- Ty Jones as Watkins, the chief of police
- Bear Allen-Blaine as Mrs. Jarvis, Emily's faithful lawyer who helps her save Clifford from Lyfegro.