DeVito and his wife, Rhea Perlman, founded Jersey Films, a production company known for films such as Pulp Fiction, Garden State, and Freedom Writers. DeVito also owns Jersey Television, which produced the Comedy Central series Reno 911!. DeVito and Perlman also starred together in his 1996 film Matilda, based on Roald Dahl's children's novel. He currently stars as Frank Reynolds on the FXsitcom It's Always Sunny in Philadelphia.
He also directs and produces graphic short horror films for his Internet venture "The Blood Factory." He has appeared in several of them, as have friends of his and members of his family