The film earned positive reviews from critics, and grossed over $543 million worldwide, against a budget of $69 million. It launched the Despicable Me franchise with a series of films, including the sequel Despicable Me 2 in 2013, and the prequel Minions released in 2015 and featuring Gru's Minions as the main characters. Another sequel, Despicable Me 3, is scheduled for release in 2017.
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the entire movie.
Gru and his Minions steal the shrink ray from a secret base in East Asia, but the up-and-coming supervillain, Vector, who was also responsible for the Pyramid theft, immediately steals it from Gru, as revenge for freezing his head earlier. Gru attempts to break into Vector's fortress to get the shrink ray back, but is defeated by numerous booby traps. However, he notices three orphan girls, Margo, Edith, and Agnes, who are able to easily walk into the base because they are selling cookies. Gru disguises himself as a dentist and adopts the girls from Miss Hattie's Home for Girls, planning on using them to infiltrate Vector's base so he can get the shrink ray back. However, Gru has difficulty nurturing them properly due to their rambunctiousness, their ballet classes, and his own ineptitude as a parent.
Eventually, Gru and the girls arrive at Vector's fortress and Gru manages to steal the shrink ray. The girls then suggest a day at a theme park; Gru agrees, believing he can abandon the girls there, but he is later told by an attendant that they must be accompanied by an adult. He is then dragged around the theme park for the day, eventually warming to the girls after they compliment him on blowing up a rigged carnival game.
Later, Gru contacts Mr. Perkins, stating that he finally has the shrink ray in his possession. Margo, Edith, and Agnes interrupt the meeting, and Perkins announces that he has lost confidence in Gru and will no longer fund his operations. As Gru tells the Minions he can no longer pay them for their services, the girls offer the contents of their piggy bank to fund the plan. The Minions then hand over their own savings, too. Gru, inspired, sacrifices parts of his lair to construct a spacecraft. Gru plans to steal the Moon when it is nearest the Earth, but this ends up being the same day as the girls' ballet recital. Gru becomes conflicted, and Dr. Nefario, seeing the recital as interfering with the plan, arranges for the girls to be returned to the orphanage. At the same time, Mr. Perkins informs Vector (who is revealed to be his son) of Gru's possession of the shrink ray and the adoption of the three girls, encouraging Vector to take action.
Gru successfully shrinks and steals the Moon, but is too late to attend the recital — finding a note from Vector, who has kidnapped the girls, and will exchange the Moon for them. After arriving at Vector's headquarters, Gru readily makes the trade, but Vector reneges on the deal, flying off with the girls and the Moon, much to Gru's anger. Meanwhile, Dr. Nefario discovers that the effects of the shrink ray are temporary; the bigger the object was originally, the faster it will regain its original size. As the Moon starts to expand in Vector's ship, Gru, Dr. Nefario, and the Minions pull off a daring mid-air rescue of the girls just as the Moon explodes out of Vector's ship and launches itself back into orbit, with Vector trapped on it.
Sometime later, Gru has readopted the girls and treats them as his daughters, writing them a bedtime storybook framed around his own experience. The girls end the film by performing their own ballet recital for Gru, Marlena, Dr. Nefario, and the Minions.
- Steve Carell as Gru, a supervillain
- Jason Segel as Victor "Vector" Perkins, Mr. Perkins' son who often undermines Gru with more advanced technology
- Russell Brand as Dr. Nefario, Gru's colleague and a friendly scientist
- Julie Andrews as Marlena, Gru's mother who always berates her son
- Will Arnett as Mr. Henry Perkins, the President of the Bank of Evil and Vector's father
- Kristen Wiig as Miss Hattie, a dominating woman that runs Miss Hattie's Home for Girls
- Miranda Cosgrove as Margo, the oldest of the three girls who is known for her wit
- Dana Gaier as Edith, the middle sister of the three girls, known for her rebellious attitude
- Elsie Fisher as Agnes, the youngest of the three girls, who has an obsession with unicorns
- Pierre Coffin as Tim, Bob, Mark, Phil and Stuart, five of Gru's minions
- Chris Renaud as Dave, one of Gru's Minions
- Jemaine Clement as Jerry, one of Gru's Minions
- Danny McBride as Fred McDade, Gru's average neighbor who has difficulty understanding Gru
- Jack McBrayer as Carnival Barker/Tourist Father
- Mindy Kaling as Tourist Mother, Justin's mother
- Ken Jeong as Talk Show Host, the announcer of the news
- Global Panic
- Meet Gru
- Crime of the Century
- Home for Girls
- Bank of Evil
- Shrink Ray Theft
- Vector's Fortress
- Setting Some Rules
- Top Secret
- Pinky Promise
- Fun Land
- Cotton Candy?
- New Funding
- Sleepy Kittens
- To the Moon
- One Big Unicorn
- End Titles
- There are 11 clips in the Fandango Movie Clips in the movie.