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- John Cho as Harold Lee
- Kal Penn as Kumar Patel
- Paula Garces as Maria Perez
- Neil Patrick Harris as Neil Patrick Harris
- Ryan Reynolds as Male Nurse
- Eddie Kaye Thomas as Rosenberg
- David Krumholtz as Goldstein
- Robert Tinkler as J.D.
- Fred Willard as Dr. Willoughby
- Anthony Anderson as Burger Shack Employee
- Siu Ta as Cindy Kim
- Christopher Meloni as Freakshow
- Malin Akerman as Liane
- Jamie Kennedy as Creepy Guy
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