Twenty years after the events of the first film, the infamous board game has evolved into a video game and while cleaning out a school's basement serving detention, four teenagers find it and get sucked into the same jungle setting that Alan Parrish got sucked into all those years ago. They also become their avatars inside the game and the only way out is to play along and finish it.
- Dwayne Johnson as Dr. Smolder Bravestone
- Jack Black as Professor Shelly Oberon
- Kevin Hart as Franklin "Mouse" Finbar
- Karen Gillan as Ruby Roundhouse
- Nick Jonas as Alex
- Bobby Cannavale as John Hardin