Bloodgood was born Korinna Moon Bloodgood in Anaheim, California on September 20, 1975. Her father, Shell Bloodgood, is an American of Dutch and Irish descent, and her mother, Sang Cha, is South Korean. Her father was stationed in Korea when he met her mother. Many mistake her for having a Native American descent.
At age 17 Bloodgood became one of the Laker Girls.
In 2005 Bloodgood was ranked #99 on Maxim's magazine's Hot 100 list. She subsequently ranked #53 in 2006, #40 in 2007 and #20 in 2009.
In Day Break (2006–2007), she portrayed Rita Shelten, the girlfriend of a detective who is framed for murder and arrested in the span of a day but continually finds himself reliving that same day. In 2007, Bloodgood starred as Livia Beale in the American science-fiction television series Journeyman on NBC.
She had a role in the movie Street Fighter: The Legend of Chun-Li, which opened in February 2009. She starred as Blair Williams in Terminator Salvation, the fourth film in the Terminator series and reprised her role in the video game and the prequel series of short film Terminator Salvation: The Machinima Series.
In early 2009 she joined the third season of the show Burn Notice in a recurring role as Detective Michelle Paxson.
She currently portrays Dr. Anne Glass in TNT's science fiction series Falling Skies executively produced by Steven Spielberg. In 2012, Bloodgood won the "Dramatic Special Jury" Prize for ensemble acting in The Sessions with John Hawkes, Helen Hunt and William H. Macy.
She also voice acts the role of Uriel the Archangel in the video game Darksiders.