Divine's friend Bob Adams described the trailer set as a "hippie commune" in Phoenix, Maryland, and noted that their living quarters were in a farmhouse without hot water. Adams added that ultimately Divine and Van Smith decided to sleep at Susan Lowe's home in Baltimore, and that they would awake before dawn to apply Divine's makeup before being driven to the set by Jack Walsh. "Sometimes Divy would have to wait out in full drag for Jack to pull the car around from back, and cars full of these blue-collar types on their way to work would practically mount the pavement from gawking at him," Adams said.
Divine's mother, Frances, later said she was surprised that her son was able to endure the "pitiful conditions" of the set, noting his "expensive taste in clothes and furniture and food".
Shot on a budget of only $10,000, Pink Flamingos is an example of Waters' style of low-budget filmmaking inspired by New York underground filmmakers like Kenneth Anger, Andy Warhol, and brothers Mike and George Kuchar. Stylistically, it takes its cues from "exaggerated seaport ballroom drag-show pageantry and antics" with "classic '50s rock-and-roll kitsch classics". Waters' idiosyncratic style – also characterized by its "homemade Technicolor" look, the result of high amounts of indoor paint and make-up – was dubbed the "Baltimore aesthetic" by art students at Providence.