Set at the beginning of the universe, the Eternals - an immortal alien race created by the Celestials - are sent to Earth to protect humanity from their evil counterparts, the Deviants.
- Angelina Jolie as Thena
- Richard Madden as Ikaris: An Eternal "fueled by cosmic energy".
- Kumail Nanjiani as Kingo
- Lauren Ridloff as Makkari: An Eternal. She is the first deaf superhero in the MCU.
- Brian Tyree Henry as Phastos
- Salma Hayek as Ajak: The leader of the Eternals.
- Lia McHugh as Sprite
- Don Lee as Gilgamesh
- Barry Keoghan as Druig
- Gemma Chan as Sersi
- Kit Harington as Dane Whitman